Binding abilities of polyaminocyclodextrins: polarimetric investigations and biological assays

• Marco Russo,
• Daniele La Corte,
• Annalisa Pisciotta,
• Serena Riela,
• Rosa Alduina and
• Paolo Lo Meo

Beilstein J. Org. Chem. 2017, 13, 2751–2763, doi:10.3762/bjoc.13.271

• calcium chloride in the preparation of competent cells pointless. Conclusion The binding abilities of AmCDs as bimodal supramolecular ligands were successfully tested towards neutral and anionic p-nitroaniline derivatives, sodium alginate and the pUC19 plasmid DNA, chosen as suitable models. First

Synthesis, characterization and DNA interaction studies of new triptycene derivatives

• Sourav Chakraborty,
• Snehasish Mondal,
• Rina Kumari,
• Sourav Bhowmick,
• Prolay Das and
• Neeladri Das

Beilstein J. Org. Chem. 2014, 10, 1290–1298, doi:10.3762/bjoc.10.130

• ; ethynyl; pUC19 plasmid; triptycene tripod; Introduction Triptycene is the simplest member of the class of compounds called iptycenes. Structurally, iptycenes have a number of arene rings joined together to form the bridges of [2.2.2]bicyclic ring systems. In triptycene, the bicyclic ring is decorated

• spectrum of the product 7 and 8 between 8.9–9.1 ppm confirms the formation of triphosphines. Biological studies: Interaction of triptycene derivatives with DNA All the triptycene derivatives, when incubated with plasmid DNA show different degree of nuclease activity on supercoiled pUC19 plasmid DNA. The

• : pUC19 plasmid, Uracil DNA Glycosylase (UDG) enzyme, APE1 enzyme, BamHI, and HindIII restriction endonucleases were purchased from New England Biolabs (USA). HPLC-purified monouracil-containing synthetic deoxyoligomers were purchased from Sigma-Aldrich and deoxyoligomer concentrations were adjusted as